Title: Electrosprayed Nanosystems of Carbamazepine – PVP K30 for Enhancing Its Pharmacologic Effects
Journal: Iranian journal of pharmaceutical research
Author: 1,2. Deniz Abedinoghli, Karim Osouli-Bostanabad, Sevil Selselehjonban, Shahram Emami, 1,4. Khosro Adibkia, 3. Mohammad Charkhpour, 4,5. Mohammad Barzegar-Jalali
Year: 2018
Address: 1. Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran 2. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran 3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran 4. Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran 5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: This study was conducted to enhance the pharmacologic effect of carbamazepine (CBZ) (as a poorly water-soluble drug) by fabricating CBZ-PVP K30 nanobeads using an electrospraying technique. CBZ-PVP K30 nanosystems with various ratios (1:3 and 1:5) at total solution concentrations of 3% and 5% w/v were prepared. The solution concentration extremely affected the size of the samples; where, the nanobeads (mean diameter of 457.65 ± 113.72 nm and 1.16 ± 0.46 µm) were developed at low and high solution concentrations, respectively. DSC thermographs and PXRD patterns precisely showed CBZ amorphization in the electrosprayed nanosystems. Based on the FTIR spectrum of the electrosprayed samples, a feasible interaction between N–H/O–H group of CBZ and PVP carbonyl group was detected. The in-vitro release studies revealed that the electrosprayed nanosystems represent a comparable rapid dissolution rate with respect to the physical mixtures (PMs) and the pure drug. The in-vivo results in NMRI mice indicated that the electrosprayed nanoformulation (with the drug: polymer ratio of 1:5 at a total solution concentration of 5% (w/v)) prolonged seizure latency time and decreased mortality percent in strychnine (STR) induced seizure mice more effciently than the PM. Our finding revealed that the electrospraying as a cost-beneft and one step technique could be effectively applied for improving the physicochemical characteristics and pharmacologic effect of CBZ.
Keywords: Carbamazepine, PVP K30, Electrospray, Nanobeads, In-vivo evaluation
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
URL: #https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269578/#