مقالات منتشر شده با محصولات



Title: Doxorubicin hydrochloride - Loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers for hyperthermic tumor cell treatment and controlled drug release
Journal: International Journal of Biological Macromolecules
Author: 1. Maryam Radmansouri, 2. Ehsan Bahmani, 3. Einollah Sarikhani, Keivan Rahmani, 4. Fariborz Sharifianjazi, 5. Mohammad Irani
Year: 2018
Address: 1. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran 2. Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran 3. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran 4. Department of Metallurgy & Material Engineering, Golpayegan University of Technology, Golpayegan, Iran 5. Young Researchers & Elite Club, Tehran North Branch, Islamic Azad University, Tehran, Iran
Abstract: In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample magnetometer (VSM) analysis. The DOX loading efficiency and in vitro drug release of DOX from nanofibers were investigated at both physiological and acidic conditions by an alternating of magnetic field and without magnetic field effect. The fastest release of DOX from prepared magnetic nanofibers was observed at acidic pH by alternating of magnetic field. The antitumor activity of synthesized nanofibers was also investigated on the melanoma cancer B16F10 cell lines. The obtained results revealed that the DOX loaded-electrospun chitosan/cobalt ferrite/titanium oxide nanofibers can be used for localized cancer therapy.
Keywords: Doxorubicin hydrochloride, Nanofibers, Chitosan, Hyperthermia, Chemotherapy
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
URL: #https://www.sciencedirect.com/science/article/pii/S0141813018302319#