Title: Novel electro-conductive nanocomposites based on electrospun PLGA/CNT for biomedical applications
Journal: Journal of Materials Science: Materials in Medicine
Author: 1. Niloofar Nazeri, Reza Faridi-Majidi, Hossein Ghanbari, 2. Mohammad Ali Derakhshan
Year: 2018
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract: Electro-conductive nanocomposites have several applications in biomedical field. Development of a biocompatible electroconductive polymeric materials is therefore of prime importance. In this study, electro-conductive nanofibrous mats of PLGA/CNT were fabricated through different methods including blend electrospinning, simultaneous PLGA electrospinning and CNT electrospraying and ultrasound-induced adsorption of CNTs on the electrospun PLGA nanofibers. The morphology and diameter of fibers were characterized by SEM and TEM, showing the lowest average diameters of 477 ± 136 nm for PLGA/MWCNT blend nanocomposites. MWCNT-sprayed PLGA specimens showed significant lower water contact angle (83°), electrical resistance (3.0 × 104 Ω) and higher mechanical properties (UTS: 5.50 ± 0.46 MPa) compared to the untreated PLGA scaffolds. Also, results of PC12 cell study demonstrated highest viability percentage on the MWCNTsprayed PLGA nanofibers. We propose that the conductive nanocomposites have capability to use as tool for the neural regeneration and biosensors.
Keywords:
Application: Nanocomposite
Product Model 1: Electroris
Product Model 2:
URL: #https://link.springer.com/article/10.1007/s10856-018-6176-8#