Title: Fabrication and characterization of chitosan beads as a controlled release drug delivery system of theophylline
Journal: structure
Author: 1. Movaffagh J., 2. Sajadi Tabassi S.A., 3. Rastgoo A., 4. Amiri N., 5. Shariatnia F.
Year: 2014
Address: 1. Targeted Drug Delivery Research Center, Stem Cell Center and Dept. of Pharmaceutics, School of Pharmacy, Mashhad
University of Medical Sciences, PO Box 91775-1365, Mashhad, Iran
2. Pharmacological Research Center of Medicinal Plants, School of Medicine and Dept. of Pharmaceutics, School of
Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3. Dept. of enviromental health, School of health, Mashhad University of Medical Sciences, Mashhad, Iran
4. Targeted Drug Delivery Research Center, Dept. of Pharmaceutics, School of Pharmacy, Mashhad University of Medical
Sciences, Mashhad, Iran
5. Targeted Drug Delivery Research Center, pharm D student, School of Pharmacy, Mashhad University of Medical Sciences,
Abstract: Chitosan is a biodegradable and biocompatible polymer
which has received much attention in recent years as an
oral drug delivery vehicle for controlled-release
formulations. In the present study chitosan beads were
prepared by an ionotropic gelation method with
tripolyphosphate (TPP) and loaded with theophylline
using high MW of chitosan. The beads were
characterized for shape and surface morphology by
electron microscope. Loading efficiency of beads was
determined by UV spectrophotometric method. Drug
release profile and swelling behavior were studied in
buffer pH 7.4. The results of this study showed that
chitosan beads with nearly spherical shape and smooth
surfaces with about 93% drug loading. Swelling studies
revealed that chitosan beads were able to absorb 1.5
fold as much water as their initial weight. Drug release
profile from chitosan beads showed that the release of
theophylline increases with time with a steeper slope up
to 6 hours and levels off afterwards reaching 30% in 12
hours. This means that a sustained release system of
theophylline has been obtained which can release the
drug in a slow yet continuous manner. The beads were
3-4 mm in diameter. It can be concluded that chitosan
can be used as a biomaterial vehicle for preparation of
controlled release beads loaded with theophylline. It
was shown that the release of theophylline from
chitosan beads has a two phase pattern and controlled
by more than one mechanism.
Keywords:
Application: Drug Delivery
Product Model 1: Syringe Pump (SP1000)
Product Model 2:
URL: http://www.ari.ir/abstractspdf/959.pdf#="http://www.ari.ir" & "/abstractspdf/959.pdf"#