Title: Preparation and in-Vitro Characterization of Electrospun Bioactive Glass Nanotubes as Mesoporous Carriers for Ibuprofen
Journal: Ceramics International
Author: 1. Neda Ghaebi Panah, Parvin Alizadeh, 2. Bijan Eftekhari Yekta, 3. Negar Motakef-Kazemi
Year: 2016
Address: 1. Ceramic Group, Department of Materials Science & Engineering, Faculty of Engineering & Technology, Tarbiat Modares University, P.O.Box: 14115-143, Tehran,Iran 2. Ceramic group, School of Metallurgy and Materials Engineering, Iran University of Science and Technology (IUST), P.O. Box: 16846-13114,Tehran, Iran 3. Department of Nanochemistry, Faculty of pharmaceutical chemistry, Pharmaceutical sciences branch, Islamic Azad University (IAUPS), Tehran, Iran
Abstract: 59SiO2–36CaO–5P2O5 (mol%) as58Sbioactiveglassnanotubesweresuccessfullypreparedusingacoaxial electrospinning process,loadedwithIbuprofen(IBU),andcharacterizedforin-vitrodrugreleaseprop- erties. Polyvinylpyrrolidone(PVP)wasexploitedtomanipulatetheprecursorsolutionsviscosity.The influence ofPVPconcentrationon fiber formationanditsmorphologywereinvestigated.Theacceptable formation wasachievedeventuallybydissolving8gPVPin10mlethanol.Bioactiveglassnanotubes werecharacterizedby field emissionscanningelectronmicroscopy(FE-SEM),X-raypowderdiffraction (XRD), simultaneousthermalanalysis(STA-TG/DTA),nitrogensorptionporosimetry(BET),Fourier transform infraredspectroscopy(FT-IR),thermogravimetricanalysis(TGA),ultraviolet-visibleabsorption spectroscopy(UV–vis), andenergydispersivespectroscopyanalysis(EDS).Accordingly,FT-IRandTG analysesindicatedthesynthesisofbioactiveglassnanotubeshasasatisfactoryabilitytostoreIBUdueto hydrogenbondingbetweendrugandglass.Furthermore,in-vitrodrugreleasetestsverified thatsamples of drug-loadedglassnanotubeswerebasedonKorsmeyer-PeppasmodelandFickiandiffusionrelease mechanism. Thesurfaceof58Sglassnanotubeswasfullycrystallized,mostlybyhydroxylapatitephase and partiallybytetracalciumphosphatelayerafterimmersioninSBFfor14days.
Keywords: Coaxial electrospinning Drug delivery Drug-loaded nanotubes Mesoporous carriers
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
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