Title: Fabrication and characterization of tretinoin-loaded nanofiber for topical skin delivery
Journal: Biomaterials Research
Author: 1. Saba Khoshbakht, 2,3. Farzin Asghari-Sana, Anahita Fathi-Azarbayjani, 4. Yaeghob Sharifi
Year: 2020
Address: 1. Student Research Committee, Urmia University of Medical Science, Urmia, Iran 2. Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran 3. Department of Pharmaceutics, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran 4. Department of Clinical Microbiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Abstract: Background: Tretinoin or all-trans retinoic acid is used in the treatment of acne vulgaris and photo-aging. This work aims to develop tretinoin-loaded nanofibers as a potential anti-acne patch and to investigate its physicochemical characteristics. Method: Nanofibers were produced via electrospinning method and surface topography was evaluated by Field Emission Scanning Electron Microscopy (FESEM). The functional groups of polymer and the drug molecule and the possible interactions were studied by Fourier Transform Infrared Spectroscopy (FTIR). Drug release studies were carried out by total immersion method at 25 °C and 32 °C. Tretinoin stability was evaluated at room temperature and fridge for 45 days. The possibility of synergistic antibacterial activity of tretinoin and erythromycin combination was investigated on Staphylococcus aureus (ATCC® 25923™) and (ATCC® 29213™) by Kirby Bauer disc diffusion method. Results: Uniform fibers without drug crystals were fabricated via electrospinning. Drug-loaded nanofibers show inherent stability under various storage conditions. Electrospun nanofibers showed a prolonged release of tretinoin. The stability of formulations in FT was higher than RT. Disc diffusion tests did not show any synergism in the antibacterial activity of erythromycin when used in combination with tretinoin. Conclusion: It can be anticipated that the easy fabrication, low costs and dosing frequency of the construct reported here provide a platform that can be adapted for on-demand delivery of tretinoin.
Keywords: Tretinoin, Erythromycin, Nanofiber, Stability, Drug release
Application: Drug Delivery
Product Model 1: Syring Pump (SP1000HOM)
Product Model 2: High Voltage Power Supply (HV35POV)
URL: #https://link.springer.com/article/10.1186/s40824-020-00186-3#