Title: Encapsulation and Controlled Release of Vitamin B2 Using Peracetyl-β-Cyclodextrin Polymer-Based Electrospun Nanofiber Scaffold
Journal: Pharmaceutical Chemistry Journal
Author: 1. Abolfazl Heydari, 2. Fatemeh Mehrabi, Tayebeh Shamspur, Hassan Sheibani, Ali Mostafavi
Year: 2018
Address: 1. Young Researchers and Elite Club, Kerman Branch, Islamic Azad University, 76169 Kerman, Iran 2. Department of Chemistry, Shahid Bahonar University of Kerman, 76169 Kerman, Iran.
Abstract: Hydrophobic β-cyclodextrin polymer nanofibers were obtained by the electrospinning of peracetylβ-cyclodextrin polymer (AcβCDP) from acetone : DMF (3 : 2 v/v) solution. The morphology of AcβCDP nanofibers was studied by scanning electron microscopy. The proposed novel hydrophobic β-CD polymer was synthesized through reaction of water-soluble β-CD polymer crosslinked with epichlorohydrin (β-CD-ECH polymer) and acetic anhydride in the presence of pyridine. The peracylation of β-CD-ECH polymer is verified by FT-IR and solubility data. The final part of this study is focused on incorporating vitamin B2 (VB2) into the AcβCDP nanofiber. In vitro release of VB2 from AcβCDP/VB2 nanofiber in model physiological media was investigated; the results exhibited initial burst and then slow drug release. The release of VB2 from AcβCDP/VB2 nanofiber is slower than from AcβCDP/VB2.
Keywords: nanofiber, peracylated β-cyclodextrin polymer, electrospinning, vitamin B2, controlled release.
Application: Scaffold
Product Model 1: Electroris
Product Model 2:
URL: #https://link.springer.com/article/10.1007/s11094-018-1759-8#