Title: Fabrication and Characterization of Electrospun Plla/Collagen Nanofibrous Scaffold Coated with Chitosan to Sustain Release of Aloe Vera Gel for Skin Tissue Engineering
Journal: Biomedical Engineering: Applications, Basis and Communications
Author: 1. Majid Salehi, 2. Saeed Farzamfar, 3. Farshid Bastami, 4. Roksana Tajerian
Year: 2016
Address: 1. Department of Tissue Engineering and Cell Therapy School of Advanced Technologies in Medicine Tehran University of Medical Sciences, Tehran, Iran 2. Department of Medical Nanotechnology School of Advanced Technologies in Medicine Tehran University of Medical Sciences, Tehran, Iran 3. Research Institute of Dental Sciences, Dental School Shahid Beheshti University of Medical Sciences, Tehran, Iran 4. Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine Tehran University of Medical Science International Campus (TUMS-IC), Tehran, Iran
Abstract: Background and aim: Healing of ¯re-induced wounds has been still a challenge in clinical issues. The aim of this study was to fabricate a nano¯brous poly (L-lactic acid)/collagen (PLLA/COL) sca®old with sustained release of aloe vera (AV) gel using a chitosan (CT)-coated layer for skin tissue engineering applications. Material and methods: Morphology, porosity, tensile strength, hydrophilicity, degradation rate, water vapor permeability and water uptake ratio of the sca®old were characterized. The behaviors of mouse ¯broblasts (L929) were evaluated on the sca®old. Results: We observed that although the porosity of the sca®old was decreased, other characteristics were enhanced by coating a CT layer. The sca®old supports attachment, viability and proliferation of mouse ¯broblasts. Conclusion: Consequently, the PLLA/COL sca®old coated with CT for sustained release of AV gel can be considered as a desirable sca®old for skin tissue engineering.
Keywords: Electrospinning; Skin tissue engineering; Collagen; Aloe vera gel; Poly (L-lactic acid).
Application: Scaffold, Tissue Engineering
Product Model 1: High Voltage Power Supply (HV100P OV)
Product Model 2: Syringe Pump (SP1000)
URL: http://www.worldscientific.com/doi/abs/10.4015/S1016237216500356#="http://www.worldscientific.com" & "/doi/abs/10.4015/S1016237216500356"#