Title: Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs
Journal: Polymers
Author: 1.Shahla Khalili ,1.Nazanin Ghane ,1.Saied Nouri Khorasani ,2.Fariba Heydari,3,4.Arjan Atwal and 3,4.Pooya Davoodi
Year: 2022
Address: 1.Department of Chemical Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran 2.Torabinejad Dental Sciences Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran 3.School of Pharmacy and Bioengineering, Hornbeam Building, Keele University, Staffordshire ST5 5BG, UK 4.Guy Hilton Research Centre, Institute of Science and Technology in Medicine, Keele University, Staffordshire ST4 7QB, UK
Abstract: A coaxial nanofibrous scaffold of poly (ε-caprolactone) and gelatin/cellulose acetate encapsulating anti-inflammatory and antibacterial drugs was co-electrospun for skin tissue regeneration. Indomethacin and ciprofloxacin as model drugs were added to the core and the shell solutions, respectively. The effect of the drugs’ presence and crosslinking on the scaffold properties was investigated. TEM images confirmed the core–shell structure of the scaffold. The fiber diameter and the pore size of the scaffold increased after crosslinking. The tensile properties of the scaffold improved after crosslinking. The crosslinked scaffold illustrated a higher rate of swelling, and a lower rate of degradation and drug release compared to the uncrosslinked one. Fitting the release data into the Peppas equation showed that Fickian diffusion was the dominant mechanism of drug release from the scaffolds. The results of biocompatibility evaluations showed no cytotoxicity and suitable adhesion and cell growth on the prepared core–shell structure. The antibacterial activity of the scaffolds was studied against one of the most common pathogens in skin wounds, where the existence of ciprofloxacin could prevent the growth of the Staphylococcus aureus bacteria around the scaffold. The obtained results suggested a new coaxial nanofibrous scaffold as a promising candidate for simultaneous tissue regeneration and controlled drug release.
Keywords: Core–shell nanofibers, Electrospinning; Gelatin, Cellulose acetate, Poly (ε-caprolactone), Antibacterial activity, Drug release
Application: Antibacterial Properties
Product Model 1: Electroris
Product Model 2:
URL: #https://www.mdpi.com/2073-4360/14/13/2565#